Jan 19, 2026

Creatine vs. Protein: Which Fuels Muscle Gain Better?

Table of Contents

  1. Introduction
  2. Understanding the Building Blocks: What is Protein Powder?
  3. The Powerhouse: What is Creatine?
  4. How They Work for Muscle Gain: Different Paths to a Similar Goal
  5. The Bioavailability Factor: Why Quality Matters for Every Supplement
  6. Creatine vs. Protein for Muscle Gain: A Direct Comparison
  7. Synergy: Why Combining Them Can Be Beneficial
  8. Setting Realistic Expectations: Consistency is Key
  9. Choosing the Right Forms for Your Lifestyle
  10. Conclusion
  11. Frequently Asked Questions

Introduction

Embarking on a fitness journey, particularly one focused on building muscle and enhancing physical performance, often leads to a common crossroads: "Which supplements truly make a difference, and how do they work?" Among the vast array of options, creatine and protein powder stand out as two of the most researched and widely used by individuals striving for muscle gain. While both are celebrated for their roles in supporting physical development, they operate through distinct mechanisms within the body. Understanding these differences isn't just about picking one over the other; it's about making informed choices that align with your unique goals, training style, and overall wellness philosophy.

This article will delve into the individual benefits and actions of both creatine and protein powder, exploring how each contributes to muscle growth and strength. We’ll compare their roles, discuss why quality and absorption are paramount for any supplement you choose, and offer practical guidance on how to integrate them effectively into your regimen. By the end, you'll have a clear picture of whether creatine or protein powder is "better" for your specific weight gain aspirations, or if perhaps, a synergistic approach is the key.

Understanding the Building Blocks: What is Protein Powder?

Protein is an essential macronutrient, often called the "building block of life" because it’s vital for the structure and function of every cell in your body, especially muscle tissue. For anyone looking to build muscle or enhance recovery, adequate protein intake is non-negotiable. Protein powder, in its various forms, offers a convenient and efficient way to supplement dietary protein.

The Role of Amino Acids

At its core, protein is made up of amino acids. These are the smaller units that, when linked together, form long chains that fold into complex protein structures. There are 20 different amino acids, nine of which are considered "essential" because your body cannot produce them on its own and must obtain them through diet.

When you consume protein, your digestive system breaks it down into individual amino acids, which are then absorbed and used by your body for various processes, including muscle protein synthesis (MPS). MPS is the biological process by which new muscle proteins are formed, repairing muscle damage caused by exercise and leading to muscle growth over time.

Whey protein, a popular choice, is particularly rich in branched-chain amino acids (BCAAs), especially leucine. Leucine is considered a key signaling molecule that directly stimulates MPS, making whey protein an excellent post-workout option for jumpstarting the recovery and growth process.

Benefits of Protein Powder for Muscle Gain

  • Muscle Repair and Growth: By providing a readily available source of amino acids, protein powder helps repair the microscopic tears in muscle fibers that occur during resistance training. This repair process is what ultimately leads to stronger, larger muscles.
  • Convenience and Efficiency: Meeting high protein targets through whole foods alone can be challenging, especially for individuals with busy schedules or specific dietary preferences. Protein powder offers a quick, portable, and often palatable way to boost protein intake without extensive meal preparation. A simple shake can deliver 20-25 grams of high-quality protein efficiently.
  • Satiety and Metabolism: Protein is known for its ability to promote feelings of fullness, which can be beneficial whether your goal is muscle gain or healthy weight management. Maintaining muscle mass also supports a higher resting metabolic rate, meaning your body burns more calories at rest.

At Cymbiotika, we understand that protein intake is foundational. We prioritize the highest quality ingredients in our offerings, emphasizing purity and transparency to ensure you’re getting exactly what your body needs without hidden fillers. While we don't offer a traditional whey protein powder, we provide foundational support for your protein and amino acid needs through other formulations. For instance, our Liquid Colostrum provides a rich source of growth factors, immunoglobulins, and amino acids that may support muscle recovery and overall vitality. Similarly, a balanced diet supported by our Super Greens can help ensure a broad spectrum of nutrients that contribute to your body's ability to utilize the protein you consume, supporting everything from gut health to cellular repair.

The Powerhouse: What is Creatine?

Creatine is an organic compound naturally produced in the body, primarily in the liver, kidneys, and pancreas, from amino acids like arginine, glycine, and methionine. It's stored predominantly in your muscle cells, where about 95% of the body's creatine supply resides. Small amounts are also found in the brain and other tissues. You also get creatine from your diet, especially from red meat and fish.

How Creatine Boosts Performance

The primary function of creatine is to help regenerate adenosine triphosphate (ATP), which is the body's main energy currency. During high-intensity, short-duration activities like weightlifting or sprinting, your body rapidly depletes its ATP stores. Creatine helps quickly replenish ATP by donating a phosphate group to adenosine diphosphate (ADP) to re-form ATP. This process, known as the phosphocreatine system, allows your muscles to sustain powerful contractions for longer periods before fatiguing.

When you supplement with creatine, you increase the phosphocreatine stores in your muscles. This heightened availability of energy allows you to perform more reps, lift heavier weights, or sprint faster during your workouts. Over time, this enhanced exercise capacity translates to greater training stimulus, which is crucial for triggering muscle growth and strength adaptations.

Benefits of Creatine for Muscle Gain

  • Increased Strength and Power: By providing more immediate energy, creatine may help you push past previous plateaus, leading to noticeable improvements in strength and power output during your resistance training sessions. Many people find they can lift heavier or complete more repetitions.
  • Enhanced Exercise Performance: This translates to a better overall workout, allowing for a higher volume and intensity of training, which are key drivers of muscle hypertrophy (growth).
  • Muscle Cell Volumization: Creatine draws water into muscle cells, leading to an increase in cell volume. This "volumizing" effect can make muscles appear fuller and may also play a role in signaling pathways that promote muscle growth.
  • Faster Recovery Between Sets: The rapid regeneration of ATP means your muscles can recover more quickly between high-intensity sets, enabling you to maintain performance throughout your workout.

While creatine itself is not a Cymbiotika product, we understand the science behind foundational health and performance. Just as creatine helps optimize cellular energy, our mission at Cymbiotika is to empower you with supplements that support your body's innate capabilities. We believe that regardless of your performance goals, a strong foundation of well-absorbed nutrients is key. This includes ensuring your body can effectively utilize everything you consume, from the food on your plate to any supplements you choose. Products like our Liposomal Vitamin B12 + B6 and Pürblack Pure Mineral Shilajit Live Resin are designed to support cellular energy production and overall vitality, creating an optimal internal environment for peak performance and recovery.

How They Work for Muscle Gain: Different Paths to a Similar Goal

When considering if creatine or protein powder is better for weight gain, it's crucial to understand that they contribute to muscle growth through distinct yet complementary pathways. They are not interchangeable but rather play different, vital roles in the muscle-building process.

Protein: The Direct Builder

Protein powder directly contributes to muscle gain by supplying the raw materials—amino acids—necessary for muscle protein synthesis. Think of it like this: your muscles are constantly undergoing a cycle of breakdown and repair. When you lift weights, you cause microscopic damage to your muscle fibers. To repair and rebuild these fibers, making them stronger and larger, your body needs a sufficient supply of amino acids. Protein powder provides these essential building blocks, accelerating the repair process and facilitating the net gain of muscle tissue.

  • Mechanism: Direct anabolic effect (muscle building).
  • Primary Contribution: Provides amino acids for muscle repair and growth.
  • Ideal Timing: Especially effective post-workout, but consistent daily intake is most important.

Creatine: The Performance Enhancer

Creatine, on the other hand, contributes to muscle gain indirectly. It doesn't directly provide the building blocks for muscle tissue. Instead, it enhances your capacity to perform high-intensity exercise. By increasing the availability of ATP, creatine allows you to:

  • Perform More Work: Lift heavier weights or complete more repetitions within a given workout.
  • Recover Faster: Between sets, enabling a higher total training volume.
  • Increase Training Stimulus: This greater workload and intensity create a stronger signal for your muscles to adapt, grow, and become stronger.
  • Mechanism: Indirect ergonomic effect (improves exercise performance).
  • Primary Contribution: Boosts strength, power, and exercise capacity, leading to greater training stimulus.
  • Ideal Timing: Consistent daily intake is key, as muscle creatine stores need to be saturated. Timing around workouts is less critical than consistent daily use.

The Interplay

The "better" choice isn't about one replacing the other, but recognizing their different contributions. Protein provides the bricks and mortar for the house (muscle), while creatine provides the enhanced energy for the construction workers (your muscles) to build that house more efficiently and robustly.

True muscle gain, or weight gain primarily in the form of lean mass, comes from a consistent combination of progressive resistance training, adequate caloric intake (often a slight surplus), sufficient protein intake, and proper recovery. Both creatine and protein powder can optimize this process, but they address different facets of it.

The Bioavailability Factor: Why Quality Matters for Every Supplement

In the world of wellness supplements, it's easy to assume that all products offering the same ingredient will deliver the same results. However, this is a significant misconception, and it's where Cymbiotika distinguishes itself. Our core differentiator, and a concept we passionately advocate for, is bioavailability.

Bioavailability refers to the degree and rate at which a substance (like a nutrient or supplement) is absorbed into your bloodstream and becomes available at the site of physiological activity. Simply put, it's about how much of what you take, your body can actually use. If a supplement has low bioavailability, much of it may pass through your system without being properly absorbed, diminishing its intended benefits.

The Cymbiotika Difference: Designed with Absorption in Mind

At Cymbiotika, we believe wellness starts with trust, and that trust is built on transparency and efficacy. This is why we are committed to sourcing high-quality ingredients and utilizing advanced delivery methods to maximize bioavailability. For many of our liquid formulations, we employ an advanced liposomal delivery approach.

What is Liposomal Delivery?

Liposomes are tiny, spherical vesicles made from phospholipids, which are similar to the natural cell membranes in your body. When nutrients are encapsulated within these liposomes, they are protected from degradation in the harsh environment of the digestive tract. This allows them to bypass traditional absorption barriers and be more efficiently delivered into the bloodstream and ultimately to your cells, where they are needed most. This targeted delivery helps ensure that the active ingredients are utilized effectively by your body, making your supplement routine more impactful.

Our Trust Pillars for Quality and Transparency

We apply rigorous quality standards to all our products, ensuring that what you take is not only effective but also pure and safe. When choosing supplements, it's important to look for brands that prioritize:

  • Third-Party Testing: Every batch of our products undergoes thorough third-party testing for purity and potency. This verifies that the ingredients listed on the label are present in the stated amounts, and importantly, that the product is free from contaminants.
  • No Unnecessary Synthetic Fillers: We believe in clean formulations. You won't find hidden ingredients, artificial binders, or unnecessary synthetic fillers in our products. This commitment to purity means your body receives only beneficial compounds.
  • Non-GMO Standards & Organic/Wild-crafted Sourcing: Where possible and appropriate, we prioritize non-GMO ingredients and ethically source organic or wild-crafted components. This ensures a cleaner product, free from genetically modified organisms and with a reduced environmental footprint.
  • GMP-Aligned Manufacturing Standards: Our manufacturing processes adhere to strict Good Manufacturing Practices (GMP) guidelines, ensuring consistency, quality, and safety at every stage of production.

Understanding bioavailability and demanding these quality standards reduces the guesswork in your wellness journey. It empowers you to make informed choices, confident that the supplements you invest in are truly working with your body, not just passing through it. This emphasis on absorption and formulation design is crucial for maximizing the benefits of any supplement, whether you're focusing on muscle gain, energy, or overall health.

Creatine vs. Protein for Muscle Gain: A Direct Comparison

When faced with the question, "is creatine or protein powder better for weight gain?" it's less about a direct competition and more about understanding which one addresses a specific need in your overall strategy for gaining lean muscle.

When Protein Powder May Take Priority

For many individuals, especially those new to resistance training or those struggling to meet their daily macronutrient targets, protein powder will likely be the more foundational supplement.

  • Meeting Protein Requirements: The most critical factor for muscle gain, after consistent training, is adequate protein intake. If your dietary protein intake is insufficient (e.g., less than 0.8-1 gram per pound of body weight for active individuals), you simply won't have enough amino acids to repair and build muscle effectively, regardless of how hard you train. Protein powder provides a convenient way to bridge this gap.
  • Supporting Recovery: Post-workout, your muscles are primed for nutrient uptake. A fast-digesting protein source can kickstart muscle protein synthesis, reducing muscle damage and accelerating recovery.
  • Beginner Focus: For a recreational gym-goer whose primary goal is to stay in shape and build some muscle, ensuring sufficient protein intake for muscle building and recovery is often the most impactful first step.

Consider a scenario where someone is consistently hitting the gym but finds it hard to consume enough protein due to a busy schedule or lack of appetite for large meals. For this individual, incorporating a high-quality protein shake could be a game-changer. While we don't offer traditional protein powders, we emphasize holistic gut health for optimal nutrient absorption, which can directly impact how well your body utilizes dietary protein. Our Probiotic is designed to support a healthy gut microbiome, which in turn may aid in the digestion and absorption of nutrients from your food, including protein.

When Creatine May Take Priority or Be Added

Creatine shines when your primary goal is to maximize strength, power, and overall training performance.

  • Breaking Plateaus: If you're already consuming enough protein and training consistently but feel stuck in your strength progression, creatine can offer that extra boost to lift heavier or perform more reps, thereby increasing the training stimulus for further growth.
  • High-Intensity Training: For athletes or individuals engaged in power sports, weightlifting, or high-intensity interval training, creatine's ability to rapidly regenerate ATP is invaluable.
  • Experienced Lifters: Those who have optimized their diet and training often look to creatine to gain an additional edge in performance and muscle mass.

It's important to remember that creatine primarily increases exercise capacity, which then leads to more muscle. It's not a direct muscle builder in the same way protein is. If your diet is poor, or your training is inconsistent, creatine alone will not magically build muscle.

The Verdict for Weight Gain (Muscle Mass)

Neither creatine nor protein powder is definitively "better" than the other for muscle gain; they simply serve different, yet equally important, functions.

  • Protein powder is fundamental. It provides the essential raw materials for muscle repair and growth. Without adequate protein, your body cannot effectively build new muscle tissue, even with the best training and other supplements.
  • Creatine is an enhancer. It allows you to perform at a higher intensity during workouts, creating a stronger stimulus for muscle growth. It optimizes the work you put in, leading to greater gains in strength and potentially muscle mass than training without it.

Therefore, the most effective strategy for gaining lean weight (muscle mass) often involves both. Protein ensures your body has the necessary building blocks, while creatine helps you maximize the effort and effectiveness of your training sessions.

Synergy: Why Combining Them Can Be Beneficial

While studies often suggest there's no added physiological benefit of taking creatine and whey protein together at the exact same time compared to taking them separately, the real benefit lies in their synergistic roles within your overall fitness regimen. They don't directly amplify each other's effects in one moment, but rather complement each other over the course of days and weeks to support comprehensive muscle growth and performance.

Think of it as building a robust house:

  • Protein provides the quality bricks and strong framework: This is your essential raw material. Consistent daily protein intake ensures your muscles have the amino acids needed for repair and growth, especially after being broken down during training.
  • Creatine powers the heavy machinery and construction crew: This allows for more efficient and forceful work. By enabling you to lift heavier and push harder in the gym, creatine creates a stronger stimulus for muscle adaptation and growth.

When you combine consistent protein intake with creatine supplementation, you're addressing both the "supply" and the "demand" aspects of muscle building. You're giving your body the necessary building blocks (protein) and simultaneously increasing your capacity to create the stimulus for growth (creatine).

Practical Integration

Many people find it convenient to take protein powder post-workout to kickstart recovery, and creatine at another point in the day (since consistent daily intake is more important than specific timing for creatine saturation). There's no evidence to suggest any negative interactions when taking them together, so if convenience is a factor, mixing them into a single shake is generally considered safe.

For someone looking to maximize both performance and recovery, a holistic approach is key. This could involve:

  • Ensuring adequate protein intake throughout the day, with a focus on post-workout recovery using a quality protein source.
  • Consistently supplementing with creatine to keep muscle stores saturated, supporting peak performance in every workout.
  • Prioritizing overall cellular health with products like NMN + Trans-Resveratrol for metabolic support or Liposomal Glutathione for cellular detoxification, both of which can contribute to greater resilience and recovery from intense training.

This combined strategy may support your journey towards greater muscle mass, improved strength, and enhanced overall physical capacity.

Setting Realistic Expectations: Consistency is Key

It's important to approach supplements with a clear understanding of their role: they supplement a well-rounded diet, consistent training, and adequate rest, they do not replace them. There’s no magic pill or powder that will instantly transform your physique. True and sustainable muscle gain is a long-term process built on consistent habits and patience.

  • Supplements are Tools, Not Miracles: While creatine and protein powder are backed by science to support muscle gain, their effects are optimized when integrated into a lifestyle that already prioritizes nutrition, exercise, and recovery. They can enhance your efforts, but they won't do the heavy lifting for you.
  • Building Consistent Habits: The most significant "supplement" for any wellness goal is consistency. Regularly hitting your workouts, maintaining a balanced diet, getting enough sleep, and consistently taking your chosen supplements are far more powerful than any single product alone.
  • Supporting Everyday Balance: Our products are designed to support your body's natural functions, contributing to overall well-being. This foundation helps ensure your body is in an optimal state to respond to training and utilize nutrients for growth and repair. Whether it's supporting energy, focus, recovery, or sleep quality, a balanced internal environment is crucial for any physical goal.
  • Results Vary: Individual responses to supplements can vary based on genetics, diet, training intensity, lifestyle, and other factors. It's important to listen to your body, track your progress, and adjust your routine as needed. We focus on providing the cleanest, most bioavailable ingredients to reduce the guesswork, so you can be confident your body has the best chance to utilize what you're providing it.

Remember, the journey to muscle gain is a marathon, not a sprint. Focus on the foundational elements first, and then strategically integrate high-quality supplements to support and amplify your hard work.

Choosing the Right Forms for Your Lifestyle

In addition to understanding the science behind supplements, selecting formats that seamlessly integrate into your daily life can significantly impact consistency and adherence. At Cymbiotika, we recognize that convenience and personal preference play a huge role in maintaining a wellness routine. We offer a variety of sophisticated delivery systems designed for optimal absorption and ease of use.

For someone who travels often and struggles to stay consistent with a complex supplement regimen, our liquid liposomal pouches can make it easier to keep a routine without overthinking it. They offer a potent, bioavailable dose in a convenient format. Other individuals might prefer the simplicity of a capsule or a powder that mixes easily into their favorite beverage.

When considering your overall fitness and muscle gain goals, think beyond just creatine and protein. A truly holistic approach to supporting your body’s ability to build and recover includes addressing other critical areas:

Supporting Energy & Performance

Optimizing your energy levels means you can push harder in your workouts and recover more effectively. Our Energy Supplements Collection offers various solutions designed to support sustained energy and focus. For instance, Liposomal Vitamin B12 + B6 can support healthy energy metabolism, while Organic Longevity Mushrooms may help support daily resilience and mental clarity. For cellular energy and vitality, consider NMN + Trans-Resveratrol, a formula designed to support cellular health and healthy aging.

Enhancing Recovery & Healthy Aging

Muscle growth occurs during recovery, not just during the workout. Supporting your body's recovery processes is paramount for consistent progress. Our Healthy Aging & Recovery Collection focuses on formulations that aid in cellular repair and reduce oxidative stress. Liposomal Glutathione, a master antioxidant, supports detoxification and cellular protection, which are vital for recovery from intense exercise. Similarly, our Liquid Colostrum provides components that may aid in tissue repair and immune function.

Prioritizing Sleep & Stress Management

Quality sleep is non-negotiable for muscle repair and hormone regulation crucial for growth. Stress can also impede recovery and progress. Our Magnesium Complex is a popular choice for supporting relaxation and sleep quality, while Liposomal Sleep offers targeted support for restful nights. The topical application of our Topical Magnesium Oil Spray can also be a soothing addition to your evening routine.

Boosting Immunity

Intense training can sometimes put a strain on your immune system. Maintaining robust immunity ensures you stay consistent with your workouts and avoid setbacks. Liposomal Vitamin C is a powerful antioxidant that supports immune function and collagen synthesis, which is crucial for connective tissue health. Meanwhile, Liposomal Vitamin D3 + K2 + CoQ10 offers broad support for immune health, bone health, and cardiovascular function.

Supporting Gut Health

A healthy gut is fundamental to overall wellness, including optimal nutrient absorption, which directly impacts how well your body utilizes protein and other nutrients for muscle growth. Our Probiotic is designed to support a balanced gut microbiome, aiding digestion and nutrient assimilation.

Beyond these specific categories, essential fatty acids like those found in The Omega are vital for cellular health, inflammatory balance, and overall well-being, all of which contribute to your body's capacity for growth and recovery.

By considering these interconnected aspects of health, you can build a truly comprehensive strategy for muscle gain and overall vitality, supported by high-quality, bioavailable supplements designed to match your lifestyle.

Conclusion

In the realm of fitness and muscle gain, the question "is creatine or protein powder better for weight gain?" ultimately leads to a nuanced answer: both are exceptionally valuable, but they serve different, complementary roles. Protein powder provides the essential amino acids—the fundamental building blocks—that your muscles need to repair and grow after intense training. Creatine, on the other hand, acts as a performance enhancer, boosting your strength and power during workouts, thereby allowing you to create a greater stimulus for muscle growth.

For optimal lean weight gain, particularly in the form of muscle mass, a synergistic approach often yields the best results. Ensure you consistently meet your daily protein requirements through diet and a high-quality protein supplement, providing your body with the necessary raw materials. Simultaneously, consider incorporating creatine to maximize your training intensity and output.

At Cymbiotika, we empower you to make informed choices by focusing on transparency, high-quality sourcing, and advanced bioavailability. We believe that what you take should actually be absorbed and utilized by your body. Whether you're supporting energy, immunity, recovery, or overall balance, our commitment to rigorous third-party testing, clean ingredients, and innovative delivery methods helps ensure you're investing in your wellness wisely.

Remember, supplements are powerful tools, but they are most effective when paired with consistent training, a balanced diet, and adequate rest. Listen to your body, track your progress, and build habits that support your long-term health and fitness goals. To discover a personalized supplement routine that aligns with your unique needs and aspirations, we invite you to explore our offerings.

Frequently Asked Questions

Q1: Can I take creatine and protein powder together?

A: Yes, you can safely take creatine and protein powder together. While studies suggest there's no additional physiological benefit to consuming them at the exact same moment versus separately, their combined use over time offers complementary benefits for muscle growth and performance. Protein provides the building blocks for muscle repair, while creatine enhances exercise capacity. Many people find it convenient to mix them into a single post-workout shake.

Q2: How much protein and creatine should I take for muscle gain?

A: For protein, individuals aiming for muscle gain often target around 0.8 to 1 gram of protein per pound of body weight daily, spread across meals and snacks. For creatine, the most common and effective approach is to take 3-5 grams per day consistently. Some individuals opt for a "loading phase" of 20 grams per day (split into 4 doses) for 5-7 days to quickly saturate muscle stores, followed by the maintenance dose of 3-5 grams daily. Always follow the label directions and consult a healthcare professional if you have any concerns.

Q3: Do I need to cycle creatine, or can I take it long-term?

A: Current research indicates that long-term, consistent use of creatine at recommended dosages (3-5 grams per day) is safe for most healthy individuals and does not require cycling. Historically, cycling (taking breaks from creatine) was common due to misconceptions, but this practice is generally not supported by modern scientific evidence. Consistency is key to maintaining saturated muscle creatine stores.

Q4: Are there any side effects to taking creatine or protein powder?

A: Both creatine and protein powder are generally well-tolerated by most healthy individuals when taken at recommended dosages. With creatine, some people may experience initial water retention, leading to a slight weight gain, or mild gastrointestinal upset, especially if taking large doses during a loading phase. High protein intake, whether from food or supplements, can sometimes lead to digestive discomfort such if consumed too quickly. Always ensure adequate hydration with any supplement regimen, and if you are pregnant, breastfeeding, taking medication, or under medical supervision, consult a healthcare professional before starting any new supplement.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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