Safety evaluation of calcium L-methylfolate
L-Methylfolate
L-methylfolate is the bioactive form of folate, a B-vitamin essential for methylation, DNA synthesis, and detoxification. The calcium component helps stabilize L-5-MTHF.
Humans cannot synthesize folate and must obtain it through food or supplements. However, up to 70% of the population carries genetic variations in the MTHFR gene that can reduce the body’s ability to convert folic acid into its active form. L-5-Methyltetrahydrofolate (L-methylfolate) bypasses this conversion step, ensuring more consistent availability of folate’s benefits. In addition, while folic acid can sometimes mask the hematological symptoms of vitamin B12 deficiency, L-5-methyltetrahydrofolate has a lower potential to do so. *
Uses pre-activated folate for maximum effectiveness. Essential for cardiovascular health, liver detoxification function , and neurotransmitter production. Complements B12 and B6 for methylation support.
Leafy greens (spinach, kale) Legumes Fortified grains (though often as folic acid, not active folate)
Did You Know?
L-methylfolate is the only form of folate that can pass through the blood-brain barrier, a border created by endothelial cells that allow nutrients into the brain. Once it passes this barrier, l-methylfolate participates in the production of the neurotransmitters serotonin, dopamine, and norepinephrine. Early in pregnancy, folate plays an important role in the neural tube development of the fetus.
SCIENTIFIC STUDIES
Want To Learn More?
Take a look at the 1,643 studies and counting, focusing on L-Methylfolate.
Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics
Folate, folic acid and 5-methyltetrahydrofolate are not the same thing
This Ingredient is Used In
Liposomal Vitamin B12 + B6
Supports Cellular Energy & Mood
