Side Effects of Licorice: What You Need to Know

Reading time:14 min

Published:April 4, 2025

Author:

Cymbiotika

Licorice root has been a staple in traditional wellness practices for thousands of years. From ancient herbal traditions to modern supplement shelves, this powerful botanical is often sought out for its ability to support digestive comfort, respiratory health, and the body’s response to stress. However, as with any potent plant-based compound, understanding how it interacts with your unique physiology is essential for maintaining balance.

Introduction

Many people are surprised to learn that the licorice found in wellness tinctures and teas is vastly different from the candy found in the grocery store aisle. Real licorice root contains complex bioactive compounds that can have significant effects on the body. While it offers many potential benefits, being aware of the side effects of licorice is a critical part of being an informed consumer.

At Cymbiotika, we believe that wellness starts with trust and transparency. This means looking beyond the marketing claims and understanding the science behind the ingredients you put into your body. In this article, we will explore the common side effects of licorice, the difference between various forms of the root, and how to build a routine that prioritizes both efficacy and safety.

Understanding the relationship between botanical potency and your personal health profile is the first step toward a more intentional wellness journey.

The Power and Potency of Licorice Root

Licorice root, scientifically known as Glycyrrhiza glabra, is native to parts of Europe and Asia. It contains over 300 different compounds, including flavonoids and various plant sterols. The most well-known and studied component is glycyrrhizin, or glycyrrhizic acid. This is the compound responsible for the root’s signature sweetness—it is significantly sweeter than sugar—and much of its biological activity.

In the wellness world, licorice is often categorized as an adaptogen. This term refers to plants that may help the body adapt to physical and environmental stressors. Many people find that licorice root supports the adrenal system, helping to maintain steady energy levels throughout a demanding day. It is also frequently used to support the integrity of the gut lining and to soothe the throat and upper respiratory system.

However, the same compound that provides these benefits—glycyrrhizin—is also the primary cause of the side effects associated with the plant. When consumed in large amounts or over long periods, glycyrrhizin can lead to a state in the body that mimics the overproduction of certain hormones. This is why the form of licorice you choose, and the way it is processed, matters so much for your daily routine.

Understanding the Side Effects of Licorice

The side effects of licorice are primarily linked to how glycyrrhizin interacts with the kidneys and the body’s electrolyte balance. While many people can enjoy licorice in moderate amounts without issue, certain individuals may experience physiological shifts that require attention.

Changes in Blood Pressure

One of the most commonly documented side effects of licorice is its impact on blood pressure. When glycyrrhizin is metabolized, it can inhibit an enzyme responsible for breaking down cortisol. This leads to an accumulation of cortisol in the kidneys, which can trick the body into holding onto sodium and excreting too much potassium.

This process often leads to increased blood pressure. For individuals who already monitor their blood pressure closely, even small amounts of regular licorice root can cause a noticeable shift. It is important to remember that these effects are usually dose-dependent, meaning they are more likely to occur with consistent, high-dose usage rather than an occasional cup of tea.

Potassium Depletion

As the body holds onto sodium, it often loses potassium in exchange. This state, known as hypokalemia, can lead to several uncomfortable experiences. Potassium is a vital electrolyte that helps muscles contract and supports nerve signaling. When levels drop too low, you might notice:

Muscle weakness or occasional cramping.
Feelings of fatigue or lethargy.
Irregularities in heart rhythm.
Digestive slowness.

Because potassium is so critical for cellular function, maintaining a balance is vital. If you are using a supplement that contains glycyrrhizin, keeping an eye on your electrolyte intake is a smart strategy.

Fluid Retention and Edema

The shift in sodium and potassium balance can also lead to fluid retention. This often manifests as swelling in the legs, ankles, or hands—a condition referred to as edema. You might notice that your rings feel tighter or that your socks leave deep indentations on your ankles at the end of the day. This puffiness is a clear signal from the body that the sodium-potassium pump is out of balance, often due to the cumulative effects of licorice compounds.

Key Takeaway: The primary side effects of licorice—increased blood pressure, low potassium, and fluid retention—are caused by glycyrrhizin’s effect on how the kidneys manage salt and water.

DGL: The Safer Alternative for Long-Term Use

Because of the potential for side effects, the supplement industry developed a specific form of the herb called Deglycyrrhizinated Licorice, or DGL. In this version, the glycyrrhizin is intentionally removed, usually leaving less than 1% of the original compound.

DGL was designed to provide the soothing benefits of licorice for the gut and throat without the risk of affecting blood pressure or potassium levels. It is the preferred choice for those who want to use licorice daily to support their digestive lining. By removing the compound responsible for most side effects, DGL offers a much higher safety profile for long-term consumption. For additional context on DGL and licorice safety, explore this guide to licorice root tea side effects.

When we formulate products at Cymbiotika, we prioritize the balance between potency and safety. Choosing the right form of an ingredient—like DGL over standard licorice for specific digestive goals—is part of our commitment to creating formulas that work with your body, not against it.

Comparing Standard Licorice and DGL

Feature
Standard Licorice Root
Deglycyrrhizinated Licorice (DGL)

Main Compound
Contains Glycyrrhizin
Glycyrrhizin Removed

Primary Use
Adrenal and respiratory support
Gut lining and digestive support

Blood Pressure Risk
Potential to increase
Minimal to no risk

Potassium Risk
Potential to deplete
Minimal to no risk

Usage Duration
Best for short-term use
Suitable for long-term daily use

Why Bioavailability Matters for Botanical Supplements

When discussing the side effects of licorice or any botanical, the question of bioavailability is central. Bioavailability refers to how much of a substance actually reaches the systemic circulation and is available for the body to use. Most standard herbal capsules are poorly absorbed because the raw plant material must be broken down by the digestive system, which is often an inefficient process.

If a supplement has low bioavailability, people often take higher doses to compensate. These high doses can increase the risk of side effects as the body struggles to process the excess material. In contrast, advanced delivery methods—like liposomal technology—are designed to wrap nutrients in a protective phospholipid layer. This layer mimics the body’s own cell membranes, allowing the ingredients to be absorbed more efficiently at the cellular level. Learn more about liposomal delivery and bioavailability.

When an ingredient is delivered more effectively, you can often achieve the desired result with a smaller, more controlled dose. This precision is key to minimizing the risk of unwanted side effects while maximizing the wellness benefits.

Bottom line: Choosing a supplement with high bioavailability means your body can use the ingredients more effectively, often reducing the need for the high doses that typically lead to side effects.

For a deeper look at how delivery methods may influence formulation decisions, read Liposomes 101.

Potential Interactions and Precautions

Licorice root does not exist in a vacuum. It interacts with the food you eat, the other supplements you take, and any medications you may be using. Understanding these interactions is a vital part of using botanicals safely.

Medication Interactions

Because licorice affects blood pressure and potassium, it can interfere with several common medications. If you are taking diuretics, blood pressure medication, or blood thinners, licorice root may alter how those medications work. For example, since some diuretics already lower potassium levels, adding licorice can cause potassium to drop to unsafe levels.

Hormonal Sensitivity

Licorice root contains phytoestrogens—plant-based compounds that can mimic the hormone estrogen in the body. While this can be beneficial for some, it may be a concern for those with hormone-sensitive conditions. If your wellness goals involve maintaining a very specific hormonal balance, it is always wise to consult with a healthcare professional before adding licorice to your routine.

Pregnancy and Nursing

Most healthcare providers recommend that pregnant and nursing women avoid products containing glycyrrhizin. Research suggests that high intake of licorice during pregnancy may affect fetal development or lead to early labor. While DGL is often considered lower risk, it is still best to prioritize caution during these sensitive life stages.

Note: If you are currently taking any prescription medications or are pregnant, consult with your primary healthcare provider before adding licorice root to your daily regimen.

How to Build a Safe Licorice Routine

If you decide that licorice root is a good fit for your wellness goals, following a few simple steps can help you avoid the side effects of licorice while reaping the rewards.

Step 1: Identify Your Goal

Are you looking for short-term respiratory support or long-term gut health? If it’s the former, a standard licorice tea or tincture may be appropriate for a few days. If it’s the latter, look for a high-quality DGL supplement. You can also explore Cymbiotika’s Gut Health collection for products focused on digestive wellness.

Step 2: Check the Label

Transparency is everything. Ensure the supplement clearly states whether it is regular licorice or DGL. Look for products that are third-party tested for purity and potency to ensure you aren't consuming hidden fillers or contaminants.

Step 3: Start Low and Go Slow

If you are new to licorice, start with a smaller dose to see how your body responds. Pay attention to how you feel—watch for any unusual puffiness, changes in energy, or muscle cramps.

Step 4: Cycle Your Usage

For standard licorice containing glycyrrhizin, many wellness experts recommend a "cycling" approach. This might mean taking the supplement for two weeks and then taking a one-week break. This prevents the compound from accumulating in your system and helps maintain a healthy potassium balance.

Step 5: Monitor Your Electrolytes

Ensure your diet is rich in potassium-heavy foods like bananas, avocados, and leafy greens while using licorice. Staying well-hydrated also helps the kidneys process the botanical compounds more efficiently.

For additional education on choosing products for digestive goals, read what to look for in a gut health supplement.

The Importance of Clean Sourcing

The quality of the licorice root itself plays a massive role in its safety profile. Plants absorb whatever is in the soil where they grow. If licorice is grown in soil contaminated with heavy metals or pesticides, those toxins can end up in your supplement.

At Cymbiotika, we prioritize sourcing that goes beyond the standard. We look for organic or wild-crafted ingredients that are processed in facilities following strict manufacturing standards. When you choose a brand that values transparency, you aren't just buying a product; you are investing in a formula that has been vetted for safety at every step of the process.

Many lower-quality supplements use synthetic fillers or binders that can interfere with the absorption of the active ingredients. These fillers can also cause digestive distress, which people sometimes mistake for the side effects of the herb itself. Choosing clean, filler-free formulations ensures that you are getting exactly what is on the label and nothing more.

Common Myths vs. Facts

Myth: All licorice supplements are the same.
Fact: There is a massive difference between standard licorice and DGL. DGL has the most common "side effect" compound removed, making it much safer for daily use.

Myth: Natural supplements can't have side effects.
Fact: Many of the world’s most powerful substances come from plants. Just because an ingredient is "natural" doesn't mean it doesn't have physiological effects that need to be managed with care.

Myth: You have to take a lot of licorice to see any effects.
Fact: With high-quality, bioavailable formulations, a little goes a long way. More is not always better, and staying within the recommended dosage is key to safety.

Finding Balance in Your Wellness Journey

Wellness is not a destination; it is a daily practice of listening to your body and making informed choices. Licorice root is a remarkable botanical with a rich history of supporting human health. By understanding the side effects of licorice and choosing the right forms and delivery methods, you can harness its power without compromising your balance.

We believe that every individual has the power to take control of their health. This starts with education and ends with a routine that is sustainable, effective, and built on a foundation of quality. Whether you are looking to support your gut with something like our Liquid Colostrum or exploring the benefits of functional mushrooms and adaptogens, the key is consistency and quality.

If you are unsure where to start with your supplement routine, we encourage you to use our Health Quiz. It is designed to help you navigate the complexities of supplementation and find a personalized path that fits your specific needs and lifestyle.

Our mission is to empower you with the tools you need to live your most vibrant life. From advanced liposomal delivery to the most transparent sourcing in the industry, we are here to support your journey every step of the way. For another perspective on bioavailability and delivery, explore this guide to supplement absorption and immune support.

Key Takeaway: Being informed about the side effects of licorice allows you to use this ancient botanical safely, ensuring your wellness routine supports your long-term health goals.

FAQ

Can I take licorice root every day?

It depends entirely on the form of licorice you are using. Deglycyrrhizinated Licorice (DGL) is generally considered safe for daily, long-term use because the compound that affects blood pressure and potassium has been removed. However, regular licorice containing glycyrrhizin should typically only be used for short periods, often no more than four to six weeks at a time.

Does licorice root affect everyone's blood pressure?

Not everyone will experience a rise in blood pressure from licorice, but the potential exists for everyone who consumes glycyrrhizin. The effect is dose-dependent, meaning the more you take and the longer you take it, the higher the risk. People who are already sensitive to sodium or have pre-existing blood pressure concerns should be particularly cautious.

How do I know if my supplement is DGL?

The supplement label should clearly state "Deglycyrrhizinated Licorice" or "DGL." If the label simply says "Licorice Root" or "Glycyrrhiza glabra" without specifying that the glycyrrhizin has been removed, you should assume it contains the full spectrum of compounds, including those that may cause side effects. Transparent brands will always make this distinction clear for the consumer.

What should I do if I experience side effects from licorice?

If you notice swelling, muscle weakness, or a change in your blood pressure while taking licorice, the first step is to stop taking the supplement and consult with your healthcare provider. In most cases, the side effects of licorice are reversible once you stop consumption and allow your body to restore its natural electrolyte balance. Your provider may suggest checking your potassium levels to ensure everything is back within a healthy range.

Liposomal Advanced Creatine

Liquid Colostrum

Liposomal Elderberry

Table of Contents

Introduction

The Power and Potency of Licorice Root

Understanding the Side Effects of Licorice

DGL: The Safer Alternative for Long-Term Use

Why Bioavailability Matters for Botanical Supplements

Potential Interactions and Precautions

How to Build a Safe Licorice Routine

The Importance of Clean Sourcing

Common Myths vs. Facts

Finding Balance in Your Wellness Journey

FAQ

Dive deeper

Frequently searched

Recommended

Liposomal Advanced Creatine

Liquid Colostrum

Liposomal Elderberry

Frequently searched

Recommended

Liposomal Advanced Creatine

Liquid Colostrum

Liposomal Elderberry

The Power and Potency of Licorice Root

Understanding the Side Effects of Licorice

DGL: The Safer Alternative for Long-Term Use

Why Bioavailability Matters for Botanical Supplements

Potential Interactions and Precautions

How to Build a Safe Licorice Routine

The Importance of Clean Sourcing

Common Myths vs. Facts

Finding Balance in Your Wellness Journey

FAQ

Frequently searched

Recommended

Liposomal Advanced Creatine

Liquid Colostrum

Liposomal Elderberry