Does Nattokinase Have Vitamin K2? Understanding the Connection

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Published:March 18, 2026

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Cymbiotika

If you have been researching ways to support your cardiovascular health, you have likely come across two names: nattokinase and vitamin K2. Both nutrients share a common origin in a traditional Japanese dish called natto. Because they are both derived from the same fermented soybean source, there is often confusion about whether a nattokinase supplement also contains vitamin K2.

Introduction

At Cymbiotika, we believe that understanding exactly what goes into your body is the first step toward true wellness. Many people assume that because an enzyme comes from a nutrient-dense food, the supplement form will carry all the food's original properties. However, the process of isolating specific compounds can change the final profile of what you consume.

This article will clarify the relationship between nattokinase and vitamin K2. We will look at how they are produced, why their presence in supplements varies, and how to choose the right option for your specific health goals. By focusing on bioavailability and nutrient absorption—how well your body can actually absorb and use these nutrients—you can build a more effective daily routine.

Quick Answer: While the whole food natto contains high levels of both nattokinase and vitamin K2, isolated nattokinase supplements usually have the vitamin K2 removed. This is often done to ensure the supplement is safe for those who must avoid vitamin K due to specific medication interactions.

What is Nattokinase?

Nattokinase is a specialized enzyme produced during the fermentation of soybeans. It is not found in unfermented soy products like tofu or soy milk. Instead, it is the byproduct of a specific bacterium called Bacillus subtilis acting on boiled soybeans. This fermentation process creates a sticky, pungent food known as natto, which has been a staple of Japanese culture for over a thousand years.

The primary role of nattokinase in the body is as a fibrinolytic enzyme. Fibrin is a protein involved in blood clotting; it forms a mesh-like structure that helps stop bleeding when you have an injury. Nattokinase is designed to support the body’s natural ability to break down excess fibrin, which may help maintain healthy blood flow and circulation.

When we talk about supplements, bioavailability is our most important metric. Bioavailability refers to the portion of a nutrient that enters the circulation and is able to have an active effect. For an enzyme like nattokinase to be effective, it must survive the digestive process and be absorbed into the bloodstream. This is why the quality of the formulation matters more than just the milligram count on the label. Cymbiotika’s liposomal delivery approach offers additional education on how formulation can influence absorption.

The Relationship Between Natto and Vitamin K2

To understand the connection between these two compounds, we have to look at the whole food source. Natto is arguably the most concentrated food source of vitamin K2 (specifically the MK-7 form) in the world. Vitamin K2 is a fat-soluble vitamin that plays a critical role in calcium metabolism. It helps direct calcium toward the bones and teeth while keeping it away from the soft tissues and arteries.

Because nattokinase is an enzyme extracted from natto, it is natural to wonder if the vitamin K2 comes along for the ride. In the raw food, they exist together. However, in the world of supplementation, they are often separated. For more background, explore what vitamin K2 does for your health.

The Isolation Process

During the manufacturing of nattokinase supplements, the enzyme is typically isolated and purified. Most high-quality manufacturers intentionally remove the vitamin K2 during this process. This creates a highly concentrated enzyme extract that serves a very specific purpose in the body without the presence of other fat-soluble vitamins.

Why Vitamin K2 is Often Removed

The decision to remove vitamin K2 is largely based on safety and precision. Vitamin K2 is known for its role in the body's clotting mechanism. While nattokinase is used to support blood "thinning" or fibrin breakdown, vitamin K2 can have the opposite effect by supporting the clotting cascade.

For individuals who are taking specific blood-thinning medications, vitamin K2 can interfere with the medication's effectiveness. By removing the vitamin K2, manufacturers allow these individuals to potentially benefit from nattokinase without the risk of a vitamin K interaction.

Does Nattokinase Have Vitamin K2? The Definitive Answer

The short answer is: No, most nattokinase supplements do not contain vitamin K2.

If you are looking at a supplement label, you should specifically check for the mention of vitamin K2 or "menaquinone." If the product is labeled as "Nattokinase (NSK-SD)" or "Vitamin K-free," the manufacturer has gone through the extra steps to strip the vitamin out.

Key Takeaway: Natto (the food) is rich in both nattokinase and vitamin K2. Nattokinase (the supplement) is an isolated enzyme that usually has the vitamin K2 removed to prevent interactions with certain medications and to focus strictly on circulatory support.

Comparing the Food vs. the Supplement

Feature
Natto (Whole Food)
Nattokinase (Supplement)

Primary Component
Whole fermented soybeans
Isolated enzyme

Vitamin K2 Content
Extremely high
Usually zero/removed

Digestive Enzymes
Multiple enzymes present
Concentrated nattokinase

Ease of Use
Acquired taste/smell
Convenient capsule/liquid

Control of Dose
Varies by batch
Standardized activity units (FU)

How Nattokinase Works in the Body

Nattokinase is unique because it acts directly on fibrin. In a healthy system, the body maintains a delicate balance between forming clots to stop injuries and dissolving those clots once they are no longer needed. Fibrinolysis is the term for this breakdown process.

As we age, our natural production of the enzymes that dissolve fibrin may decrease. This can lead to a buildup of "fibrin sludge," which may slow down circulation. Nattokinase is designed to mimic the body's own plasmin—the primary enzyme responsible for dissolving clots.

Bioavailability is a major factor here. Because nattokinase is a protein, it can be sensitive to the harsh acids in the stomach. High-quality formulations, like those we focus on at Cymbiotika, use delivery methods designed to protect the ingredient until it reaches the small intestine. This ensures that the enzyme stays intact and functional, rather than being broken down into simple amino acids before it can do its job.

The Role of Vitamin K2 in Cardiovascular Wellness

While nattokinase works on the "fluid" part of the cardiovascular system—the blood itself—vitamin K2 works on the "hardware"—the arteries and vessels.

Vitamin K2 activates a protein called Matrix Gla Protein (MGP). This protein is one of the most powerful inhibitors of arterial calcification. When calcium builds up in the arteries, it can cause them to become stiff and less responsive. By activating MGP, vitamin K2 helps ensure that calcium stays in the skeletal system where it belongs. Learn more about the best forms of vitamin K2.

Can You Take Them Together?

Many people find that taking both nattokinase and vitamin K2 provides a comprehensive approach to heart health. They do not "cancel each other out." Instead, they address different aspects of cardiovascular function.

Nattokinase supports the smoothness and flow of the blood.
Vitamin K2 supports the flexibility and structural integrity of the blood vessels.

If you choose to take them together, you are essentially recreating the nutritional profile of traditional Japanese natto, but in a controlled, standardized, and more palatable format. Cymbiotika also covers this topic in its guide to taking nattokinase and vitamin K2 together.

Why Formulation and Bioavailability Matter

At Cymbiotika, our philosophy is that a supplement is only as good as its absorption. This is especially true for delicate enzymes and fat-soluble vitamins. Standard capsules often fall short because they do not account for the biological barriers the body uses to protect itself.

Advanced Delivery Systems

Liposomal delivery is one of the most effective ways to support absorption. A liposome is a tiny bubble made out of the same material as your cell membranes (phospholipids). By wrapping a nutrient in this lipid shell, we can protect it from stomach acid and help it pass more easily through the intestinal wall and into the bloodstream.

Whether you are taking nattokinase, or another cardiovascular support like our Liposomal Vitamin D3 + K2 + CoQ10, the delivery mechanism is what dictates the results. Without proper delivery, much of what you take may simply pass through the digestive tract without being utilized.

Transparency and Purity

When choosing a nattokinase supplement, transparency is vital. You should look for:

Standardized Activity: Measured in Fibrinolytic Units (FU). A common effective dose is often cited as 2,000 FU.
Vitamin K-Free Certification: Especially important if you are monitoring your vitamin K intake.
Clean Labeling: No synthetic fillers, GMOs, or unnecessary binders that can interfere with absorption.

For broader wellness support related to vitality and recovery, explore Cymbiotika’s Healthy Aging Supplements collection.

How to Incorporate Nattokinase and Vitamin K2 into Your Routine

If you decide that these nutrients are right for you, consistency is the key to seeing any benefit. Supplements are not "quick fixes"; they are tools designed to support your body's natural processes over time.

Step 1: Consult Your Healthcare Provider

This is the most critical step. Because nattokinase affects blood flow and vitamin K2 affects clotting, you must speak with a professional if you are on any medications, particularly anticoagulants or blood pressure medication.

Step 2: Determine Your Goals

Are you primarily concerned with circulation and blood flow? Nattokinase may be your focus. Are you more concerned with bone density and arterial stiffness? Vitamin K2 (specifically MK-7) should be at the top of your list. Many people choose to stack these for broader support.

Step 3: Choose Your Timing

Nattokinase is often recommended to be taken on an empty stomach, usually before bed or first thing in the morning. This is because it is a proteolytic enzyme; if you take it with food, it may spend its energy digesting the proteins in your meal rather than entering your bloodstream to work on fibrin. Vitamin K2, being fat-soluble, is best taken with a meal that contains healthy fats to ensure maximum absorption. Cymbiotika’s guide to starting a vitamin K2 routine provides additional routine considerations.

Step 4: Monitor and Adjust

Pay attention to how you feel. Wellness is a personal journey, and what works for one person may need adjustment for another.

Bottom line: Nattokinase and Vitamin K2 are distinct compounds with different roles. While they originate from the same food, most supplements isolate them to provide targeted, safe support for circulation or calcium metabolism.

Common Myths About Nattokinase and Vitamin K2

In the wellness world, misinformation spreads quickly. Here are a few common misconceptions corrected.

Myth: All nattokinase supplements contain vitamin K2 because they come from natto.
Fact: Modern extraction techniques almost always remove vitamin K2 from nattokinase supplements to prevent medication interactions and provide a standardized dose of the enzyme alone.

Myth: Taking nattokinase will make your blood "too thin."
Fact: Nattokinase is a fibrinolytic enzyme, meaning it supports the breakdown of excess fibrin. It is designed to support the body's natural balance, not to override the entire clotting system in a healthy individual. However, results vary, and medical supervision is required for those with clotting concerns.

Myth: More milligrams always mean better results.
Fact: With nattokinase, the milligram weight is less important than the activity level (measured in FU). A 100mg capsule with high activity is better than a 500mg capsule with low activity. Furthermore, bioavailability—how much of that activity actually reaches your cells—is the ultimate decider of value.

Why We Focus on Transparency

Our mission at Cymbiotika is rooted in the belief that you deserve to know exactly what is in your supplements and why. We don't use hidden ingredients or "proprietary blends" that mask low dosages. When we talk about ingredients like nattokinase or vitamin K2, we frame them through the lens of science and purity.

We also believe that education is a form of empowerment. When you understand that nattokinase is an enzyme that dissolves "clotting mesh" and vitamin K2 is a "traffic controller" for calcium, you can make informed decisions about your routine. This is why we avoid wellness hype and stick to the biological facts of how these nutrients interact with your system.

Choosing the Best Format for You

When looking for these nutrients, you have a few options in terms of format.

Whole Food (Natto): Best for those who enjoy the taste and want the full spectrum of probiotics, fiber, and nutrients. It is the only way to get nattokinase and vitamin K2 together in a natural food matrix.
Standard Capsules: The most common supplement form. These are convenient but often lack the specialized delivery systems needed for maximum bioavailability.
Liposomal Liquids: These represent the top tier of supplement technology. By using phospholipids to encapsulate the nutrients, these formulas are designed for superior absorption and ease of use.

Our Liposomal Vitamin D3 + K2 + CoQ10 is an example of how we combine fat-soluble nutrients with advanced delivery. While it doesn't contain nattokinase, it provides the essential vitamin K2 that many nattokinase users are also seeking, delivered in a way that the body can actually utilize at the cellular level.

Conclusion

Understanding whether nattokinase has vitamin K2 is essential for anyone looking to optimize their cardiovascular health. While the traditional food natto is a powerhouse of both nutrients, the world of supplementation usually separates them for safety and precision. Nattokinase serves as a dedicated tool for circulatory support, while vitamin K2 acts as the ultimate regulator of calcium in the body.

At Cymbiotika, we encourage you to look beyond the marketing claims and focus on the formulation. Purity, transparency, and bioavailability are the pillars that make a supplement effective. Whether you are looking to support your heart, your bones, or your overall vitality, the quality of what you put in your body dictates the quality of your results.

Building a wellness routine is about more than just picking a bottle off a shelf; it's about choosing tools that align with your body's complex biological needs. If you are ready to take the next step in personalizing your health journey, we invite you to take our Health Quiz. It is designed to help you find the exact formulations that fit your lifestyle and wellness goals.

Key Takeaway: Nattokinase supplements are almost always processed to be vitamin K2-free. This allows for targeted support of blood flow without interfering with calcium-regulating pathways or specific medications. For total heart health, many people choose to supplement both separately to ensure they are getting high-bioavailability forms of each.

FAQ

Does nattokinase contain vitamin K2 naturally?

Yes, in its natural state within the fermented food natto, nattokinase exists alongside high levels of vitamin K2. However, in supplement form, the enzyme is typically isolated, and the vitamin K2 is intentionally removed to avoid potential interactions with blood-thinning medications.

Can I take nattokinase if I am already taking a Vitamin K2 supplement?

In many cases, yes, as they serve different functions in the body—one for fibrin breakdown and the other for calcium regulation. However, because both can influence cardiovascular health and blood clotting, you should always consult with your healthcare provider before combining these supplements.

Why is vitamin K2 removed from nattokinase supplements?

Vitamin K2 is removed primarily to make the supplement safer for individuals on anticoagulant medications like Warfarin. Since vitamin K2 helps support the body's clotting mechanisms, it can counteract the effects of certain medications, whereas nattokinase focuses purely on supporting healthy circulation.

What is the best way to get both nattokinase and vitamin K2?

The only way to get both from a single whole-food source is by eating natto. If you prefer supplements, the most effective approach is to look for high-quality, bioavailable versions of each—such as a liposomal vitamin K2 and a standardized, K-free nattokinase—to ensure your body can absorb and use both nutrients effectively.

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Table of Contents

Introduction

What is Nattokinase?

The Relationship Between Natto and Vitamin K2

Does Nattokinase Have Vitamin K2? The Definitive Answer

How Nattokinase Works in the Body

The Role of Vitamin K2 in Cardiovascular Wellness

Why Formulation and Bioavailability Matter

How to Incorporate Nattokinase and Vitamin K2 into Your Routine

Common Myths About Nattokinase and Vitamin K2

Why We Focus on Transparency

Choosing the Best Format for You

Conclusion

FAQ

Dive deeper

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Liposomal Advanced Creatine

Liquid Colostrum

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Frequently searched

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Liposomal Advanced Creatine

Liquid Colostrum

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What is Nattokinase?

The Relationship Between Natto and Vitamin K2

Does Nattokinase Have Vitamin K2? The Definitive Answer

How Nattokinase Works in the Body

The Role of Vitamin K2 in Cardiovascular Wellness

Why Formulation and Bioavailability Matter

How to Incorporate Nattokinase and Vitamin K2 into Your Routine

Common Myths About Nattokinase and Vitamin K2

Why We Focus on Transparency

Choosing the Best Format for You

Conclusion

FAQ

Frequently searched

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Liposomal Advanced Creatine

Liquid Colostrum

Liposomal Elderberry